Growth arrest and DNA damage-inducible proteins (GADD45) in psoriasis

Abstract The interplay between T cells, dendritic cells and keratinocytes is crucial for the development maintenance of inflammation in psoriasis. GADD45 proteins mediate DNA repair different including keratinocytes. In immune system, GADD45a GADD45b regulate function activation both lymphocytes links epigenetic regulation through its demethylase activity. Here, we analyzed expression skin, circulating a cohort psoriasis patients their by inflammatory signals. Thirty (17 male/13 female) with plaque 15 controls subjects (7 male/8 female), were enrolled. Psoriasis exhibited lower at epidermis but higher dermal infiltrating lesional skin. was also peripheral from patients, although no differences observed p38 activation. methylation state target UCHL1 evaluated, revealing hypermethylation promoter skin compared to controls. Furthermore, reduced levels correlated We propose that may account pleiotropic effects, complex heterogeneous pattern psoriatic disease.